Role for estrogen in bone marrow
The 3b-HSD gene is normally turned-on by p45 NF-E2, and encodes an enzyme that regulates all steroid hormone biosynthesis. 3b-HSD induces the production of estrogen, in the form of estradiol, in both male and female megakaryocyte cells. It was found that the addition of exogenous estradiol increased proplatlet formation by more than fifty percent, while the inhibition of estradiol receptors blocked proplatelet formation in live mice.
This could mean that patients suffering from low platelet counts, such as those with anemia, bone marrow abnormalities, or undergoing chemotherapy, may benefit from the administration of estradiol and/or a 3b-HSD activator, as an alternative to blood transfusions to increase platelet levels.
Conversely, patients with abnormally high platelet counts, who are prone to forming clots and therefore at an increased risk for strokes, heart attacks, or even miscarriage (ie. from placental clots) would be candidates for drugs designed to specifically block 3b-HSD or estradiol receptors to effectively normalize their platelet levels.
BibliographyYuka Nagata, Jun Yoshikawa, Atsushi Hashimoto, Masayuki Yamamoto, Anita H. Payne, Kazuo Todokoro (2003) Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol Genes and Development, 17:2864-2869 http://www.eurekalert.org/pub_releases/2003-11/cshl-sun112003.php
Bland.J., (2003) About Gender: Role for estrogen in bone marrow
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Last amended 31.12.03